Relationship of insight to neurocognitive function and risk of recurrence in depression: A naturalistic follow-up study

… Lack of insight may affect patients’ motivation to seek treatment, resulting in poor clinical outcomes. … Patients with MDD, without insight, had significantly higher total and factor scores (anxiety/somatization, weight, retardation, and sleep) on the HAM-D and worse performance in the neurocognition task, compared to those with insight. Furthermore, binary logistic regression revealed that insight and retardation can predict recurrence. … Lack of insight is associated with recurrence and impaired cognitive flexibility in patients with MDD.