Dealing with secondary psychiatric symptoms while treating patients in clinical settings can be quite challenging. However, in this case study, the authors discuss a female patient with Cushing’s disease, who was initially misdiagnosed with anxiety disorder. Despite multiple attempts with psychiatric intervention, her condition persisted, accompanied by unexplained hypokalemia and hypothyroidism. Thankfully, a visit to the endocrinology clinic yielded a proper diagnosis of Cushing’s disease. Subsequent medical and surgical procedures resulted in the eventual alleviation of anxiety with minimal psychotropic medication. …