Prefrontal engrams of long-term fear memory perpetuate pain perception

Nature Neuroscience, Published online: 06 April 2023; doi:10.1038/s41593-023-01291-x

Can erasing bad memories relieve pain? Stegemann et al. uncover the cellular basis of fear–pain interactions, reporting that fear potentiates pain via memories encoded in prefrontal engrams. Blocking these memory traces reduces chronic pain in mice.

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