Prefrontal engrams of long term fear memory perpetuate pain perception

Fear memory engram is the mind-killer

/ Anxiety Research, Anxiety Resources, Anxiety Treatment, Emotions and Anxiety, Fear and Anxiety, Fear and Pain, Fear Research, Pain and Anxiety / By

Nature Neuroscience, Published online: 06 April 2023; doi:10.1038/s41593-023-01292-w

Stegemann et al. have unraveled a long-lasting role for fear engrams in future pain perception. Prefrontal pain and fear representations become entangled following a fearful event. As subsequent painful experiences also reactivate the fear network, silencing the fear engram alone can alleviate both tonic pain and hypersensitivity in chronic pain.

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