depression insulin dopamine Dr Jonathan Haverkampf

Can Insulin Affect Depression by Affecting Dopamine and Reward Processing in the Brain?

Did you know that insulin affects our brain’s reward system and our motivation? This happens through its interaction with dopamine signals. Research shows that insulin resistance can have a direct impact on our brain’s dopamine signalling pathways, potentially leading to symptoms of depression and a loss of motivation. The researchers discuss how insulin affects the way dopamine signals the brain in two different regions, the ventral tegmental area (VTA) and striatum. Then, they explore the effects of insulin issues on dopamine functions. Finally, they review how insulin resistance may cause depressive symptoms and anhedonia while presenting possible solutions for treatment.

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