Condition: Postpartum CareIntervention: Other: Scenario-based high-fidelity simulation methodSponsor: Saglik Bilimleri UniversitesiCompleted
Background
Aberrant brain connectivity during emotional processing, especially within the fronto-limbic pathway, is one of the hallmarks of major depressive disorder (MDD). However, the methodological heterogeneity of previous studies made it difficult to determine the functional and etiological implications of specific alterations in brain connectivity. We previously reported alterations in psychophysiological interaction measures during emotional face processing, distinguishing depressive pathology from at-risk/resilient and healthy states. Here, we extended these findings by effective connectivity analyses in the same sample to establish a refined neural model of emotion processing in depression.
Methods
Thirty-seven patients with MDD, 45 first-degree relatives of patients with MDD and 97 healthy controls performed a face-matching task during functional magnetic resonance imaging. We used dynamic causal modeling to estimate task-dependent effective connectivity at the subject level. Parametric empirical Bayes was performed to quantify group differences in effective connectivity.
Results
MDD patients showed decreased effective connectivity from the left amygdala and left lateral prefrontal cortex to the fusiform gyrus compared to relatives and controls, whereas patients and relatives showed decreased connectivity from the right orbitofrontal cortex to the left insula and from the left orbitofrontal cortex to the right fusiform gyrus compared to controls. Relatives showed increased connectivity from the anterior cingulate cortex to the left dorsolateral prefrontal cortex compared to patients and controls.
Conclusions
Our results suggest that the depressive state alters top-down control of higher visual regions during face processing. Alterations in connectivity within the cognitive control network present potential risk or resilience mechanisms.
Face Processing in Major Depression: Pathology, Risk, and Resilience Read More »
Differentiating between intuition and fear can sometimes be challenging. Fear often manifests as a pushing energy, driving you to avoid disappointment or ridicule. Conversely, intuition exudes a pulling energy, guiding you towards what is in your best interests.
How to Tell the Difference Between Fear and Intuition Read More »
By Cara Murez HealthDay ReporterMONDAY, June 19, 2023 (HealthDay News) – New research finds that many of those who have received an implanted…
Stress, Anxiety Plague Many Who Get Implanted Heart Devices Read More »
Condition: AnxietyIntervention: Device: VeNSSponsors: Neurovalens Ltd.; Ulster UniversityCompleted
Fear of needles is a widespread issue, affecting individuals of all ages. Research suggests that up to 50% of teenagers, and at least 20 to 30% of adults experience needle fear. This problem can severely limit your life, potentially preventing you from receiving vital medical care or pursuing parenthood through in-vitro fertilization (IVF). But fear
6 Steps to Overcome a Fear of Needles Read More »
Background
Social anxiety (SA), a prevalent comorbid condition in psychotic disorders with a negative impact on functioning, requires adequate intervention relatively early. Using a randomized controlled trial, we tested the efficacy of a group cognitive-behavioral therapy intervention for SA (CBT-SA) that we developed for youth who experienced the first episode of psychosis (FEP). For our primary outcome, we hypothesized that compared to the active control of group cognitive remediation (CR), the CBT-SA group would show a reduction in SA that would be maintained at 3- and 6-month follow-ups. For secondary outcomes, it was hypothesized that the CBT-SA group would show a reduction of positive and negative symptoms and improvements in recovery and functioning.
Method
Ninety-six patients with an FEP and SA, recruited from five different FEP programs in the Montreal area, were randomized to 13 weekly group sessions of either CBT-SA or CR intervention.
Results
Linear mixed models revealed that multiple measures of SA significantly reduced over time, but with no significant group differences. Positive and negative symptoms, as well as functioning improved over time, with negative symptoms and functioning exhibiting a greater reduction in the CBT-SA group.
Conclusions
While SA decreased over time with both interventions, a positive effect of the CBT-SA intervention on measures of negative symptoms, functioning, and self-reported recovery at follow-up suggests that our intervention had a positive effect that extended beyond symptoms specific to SA.
ClinicalTrials.gov identifier: NCT02294409.
Background
Gray matter morphometry studies have lent seminal insights into the etiology of mental illness. Existing research has primarily focused on adults and then, typically on a single disorder. Examining brain characteristics in late childhood, when the brain is preparing to undergo significant adolescent reorganization and various forms of serious psychopathology are just first emerging, may allow for a unique and highly important perspective of overlapping and unique pathogenesis.
Methods
A total of 8645 youth were recruited as part of the Adolescent Brain and Cognitive Development study. Magnetic resonance imaging scans were collected, and psychotic-like experiences (PLEs), depressive, and anxiety symptoms were assessed three times over a 2-year period. Cortical thickness, surface area, and subcortical volume were used to predict baseline symptomatology and symptom progression over time.
Results
Some features could possibly signal common vulnerability, predicting progression across forms of psychopathology (e.g. superior frontal and middle temporal regions). However, there was a specific predictive value for emerging PLEs (lateral occipital and precentral thickness), anxiety (parietal thickness/area and cingulate), and depression (e.g. parahippocampal and inferior temporal).
Conclusion
Findings indicate common and distinct patterns of vulnerability for varying forms of psychopathology are present during late childhood, before the adolescent reorganization, and have direct relevance for informing novel conceptual models along with early prevention and intervention efforts.
Researchers found college students who tried to cut their social media use to 30 minutes per day scored significantly lower for anxiety, depression, loneliness and fear of missing out at the end of the two-week experiment and when compared to the control group.
Cutting back on social media reduces anxiety, depression, loneliness Read More »
A new study published in the Journal of Research in Personality reveals how curiosity can help alleviate feelings of uncertainty and anxiety. Curiosity can be divided into two categories: interest curiosity and deprivation curiosity. People high on interest-curiosity tend to hold more positive attitudes towards uncertainty. Embracing the feeling of not knowing, sparked by curiosity,
A New Way to Tame Your Anxiety Read More »
