Potential of Control Conditions for Nonspecific Treatment Effects in Noninferiority Trials

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To the Editor Hoge et al composed a well-written and interesting study examining the effect of mindfulness-based stress reduction (MBSR) vs escitalopram for the treatment of anxiety disorders. A prominent finding was that in adults with anxiety disorders, 8 weeks’ treatment with MBSR was noninferior to escitalopram.

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