Journal of Humanistic Psychology, Ahead of Print. Exposure to traumatic events or adverse experiences and its consequences have been studied mainly from a posttraumatic stress disorder perspective. Existential psychotherapy focuses on universal human concerns and the anxiety that occurs when a person confronts the conflicts inherent in life and toward death, which include the experience of difficult situations. A systematic review was performed including 56 papers that studied the relations between adverse experiences and existential concerns. The articles were assessed and described in relation to existential domains, type of adverse experience, posttraumatic responses, and existential psychological interventions. Existential concerns appeared in different degrees and categories in studied samples. Outcomes suggest that from an existential psychotherapy perspective, reactions to traumatic events can be both negative and positive for a person. In addition, the pass of time turned out to be an important factor, especially in finding meaning from traumatic experiences, the reduction of negative symptoms, and the achieving of posttraumatic growth. Existential-related interventions described in this review showed positive outcomes, suggesting that it is an effective trauma treatment approach.